Saeed, Nimra; Bryan, Alexis Michelle;Clinton, Aneisha Symone; Dipasupil, Marc Edmund Garcia; Le, Shaina Yen
College of Science and Mathematics
Professor: Dr. Hannah Wingate
ABSTRACT:
Cisplatin is a chemotherapeutic drug that has been known to induce DNA damage ultimately leading to cell death. Diruthenium is a type of ruthenium compound that has been shown to bind to DNA. The purpose of our experiment was to determine if Diruthenium induces cell death in breast cancer cells. In our experiment, we used MDA-MB-157 cells, which are mammary epithelial cancer cells. They are triple negative cells, meaning they are estrogen receptor negative, progesterone receptor negative, and Her2 receptor negative. The triple negative breast cancers are a subgroup of cancers in need of novel therapeutic strategies. We performed a MTT assay to compare the effect of different concentrations of Diruthenium to the effect of Cisplatin on the cells. We hypothesized that the Diruthenium would inhibit cell growth in a dose dependent manner.
